Issue with User Profile Disk in RDS 2012 and Excel files

Hi All,

Very strange issue. 

I have brand new RDS server 2012 R2 without User Profile Disks (UPD) enabled - all excel files are working fine.

Once i enable the UPD some excel files are not opening and the error is "The file is corrupt and cannot be opened". 

If I remove the UPD, the same excel files are opened without a problem. This is with Excel 2013. Tried to reinstall the Office, check the permissions of the UPD location - everything seems fine.

Any suggestions ?

Thanks